Hiroki Nagase Selected Research

imidazole

4/2022	Suppression of non-small-cell lung cancer A549 tumor growth by an mtDNA mutation-targeting pyrrole-imidazole polyamide-triphenylphosphonium and a senolytic drug.
12/2021	Mitochondria: Endosymbiont bacteria DNA sequence as a target against cancer.
3/2021	Targeting the mutant PIK3CA gene by DNA-alkylating pyrrole-imidazole polyamide in cervical cancer.
1/2021	Targeting anaplastic lymphoma kinase (ALK) gene alterations in neuroblastoma by using alkylating pyrrole-imidazole polyamides.
6/2020	Effects of Pyrrole-Imidazole Polyamides Targeting Human TGF-β1 on the Malignant Phenotypes of Liver Cancer Cells.
1/2018	Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhances tumor tissue accumulation/retention in vivo.
1/2016	Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome.
7/2015	Pyrrole-imidazole polyamide-mediated silencing of KCNQ1OT1 expression induces cell death in Wilms' tumor cells.
1/2015	Preclinical Study of Novel Gene Silencer Pyrrole-Imidazole Polyamide Targeting Human TGF-β1 Promoter for Hypertrophic Scars in a Common Marmoset Primate Model.
10/2014	Pyrrole-imidazole polyamide targeted to break fusion sites in TMPRSS2 and ERG gene fusion represses prostate tumor growth.

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Hiroki Nagase Research Topics

Disease

51	Neoplasms (Cancer) 05/2022 - 01/2002
13	Neuroblastoma 02/2022 - 01/2012
11	Neoplasm Metastasis (Metastasis) 05/2022 - 12/2009
9	Carcinogenesis 01/2021 - 06/2007
6	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 12/2012
5	Osteosarcoma (Osteogenic Sarcoma) 07/2021 - 01/2010
4	Adenocarcinoma 05/2022 - 03/2010
4	Squamous Cell Carcinoma (Epidermoid Carcinoma) 04/2019 - 10/2004
4	Hepatocellular Carcinoma (Hepatoma) 01/2015 - 01/2005
3	Inflammation (Inflammations) 01/2020 - 03/2009
3	Colorectal Neoplasms (Colorectal Cancer) 01/2019 - 01/2016
3	Cicatrix (Scar) 01/2015 - 03/2010
3	Hyperplasia 03/2009 - 01/2008
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 04/2022 - 01/2021
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 03/2021 - 12/2009
2	Body Weight (Weight, Body) 01/2021 - 05/2014
2	Colonic Neoplasms (Colon Cancer) 04/2015 - 09/2007
2	Melanoma (Melanoma, Malignant) 01/2015 - 08/2010
2	Brain Neoplasms (Brain Tumor) 01/2015 - 01/2010
2	Hypertrophic Cicatrix (Hypertrophic Scar) 01/2015 - 10/2011
2	Burns 01/2015 - 03/2010
2	Squamous Cell Carcinoma of Head and Neck 09/2012 - 10/2010
2	Skin Neoplasms (Skin Cancer) 07/2010 - 06/2007
2	Glioma (Gliomas) 01/2010 - 12/2009
2	Ovarian Neoplasms (Ovarian Cancer) 12/2009 - 10/2004
2	Carcinoma (Carcinomatosis) 08/2003 - 01/2002
1	Chromosome Aberrations (Chromosome Abnormalities) 12/2021
1	Lewis Lung Carcinoma 10/2021
1	Obesity 01/2021
1	Weight Loss (Weight Reduction) 01/2021
1	Esophageal Squamous Cell Carcinoma 01/2021
1	Liver Neoplasms (Liver Cancer) 06/2020
1	Alcoholism (Alcohol Abuse) 01/2020
1	Ataxia Telangiectasia (Louis Bar Syndrome) 07/2019

Drug/Important Bio-Agent (IBA)

26	Nylons (Nylon)IBA 04/2022 - 07/2008
17	DNA (Deoxyribonucleic Acid)IBA 12/2021 - 08/2003
15	imidazoleIBA 04/2022 - 03/2010
15	PyrrolesIBA 04/2022 - 03/2010
9	Proteins (Proteins, Gene)FDA Link 07/2020 - 02/2005
8	Mitochondrial DNA (mtDNA)IBA 04/2022 - 01/2010
8	Biomarkers (Surrogate Marker)IBA 01/2022 - 09/2012
7	Messenger RNA (mRNA)IBA 02/2022 - 07/2008
6	Pharmaceutical PreparationsIBA 04/2022 - 01/2020
5	Biological ProductsIBA 05/2022 - 06/2007
3	RNA (Ribonucleic Acid)IBA 05/2022 - 01/2020
3	tetraphenylporphine sulfonate (TPPS)IBA 04/2022 - 06/2021
3	Transforming Growth Factors (Transforming Growth Factor)IBA 06/2020 - 03/2010
3	1-methylimidazoleIBA 01/2020 - 10/2015
3	Small Interfering RNA (siRNA)IBA 01/2020 - 12/2009
3	Phosphotransferases (Kinase)IBA 07/2019 - 05/2005
3	Acetates (Acetic Acid Esters)FDA Link 11/2018 - 06/2007
3	Transcription Factors (Transcription Factor)IBA 04/2017 - 01/2013
3	Cisplatin (Platino)FDA LinkGeneric 04/2017 - 10/2010
3	Matrix Metalloproteinase 9 (Gelatinase B)IBA 01/2014 - 03/2010
3	hydrogen sulfite (bisulfite)IBA 01/2010 - 09/2007
3	Trefoil Factor-3IBA 07/2007 - 01/2005
2	triphenylphosphoniumIBA 04/2022 - 12/2021
2	Immune Checkpoint InhibitorsIBA 01/2022 - 10/2020
2	Histones (Histone)IBA 12/2021 - 08/2010
2	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021 - 06/2012
2	NucleotidesIBA 10/2021 - 11/2017
2	NADH DehydrogenaseIBA 01/2021 - 11/2017
2	AntigensIBA 01/2021 - 02/2005
2	Tumor Biomarkers (Tumor Markers)IBA 01/2021 - 08/2010
2	N-methylpyrroleIBA 01/2020 - 10/2015
2	PF 00477736IBA 01/2020 - 07/2019
2	Protein Serine-Threonine Kinases (Protein-Serine-Threonine Kinase)IBA 07/2019 - 05/2005
2	Doxorubicin (Adriamycin)FDA LinkGeneric 04/2017 - 01/2015
2	Leucine (L-Leucine)FDA Link 09/2016 - 10/2014
2	Codon (Codons)IBA 01/2016 - 10/2015
2	LipidsIBA 05/2014 - 03/2009
2	Matrix Metalloproteinases (MMPs)IBA 01/2014 - 03/2010
2	S100 Calcium-Binding Protein A4IBA 12/2012 - 12/2009
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2010 - 03/2009
2	Trefoil FactorsIBA 02/2005 - 01/2005
1	SenotherapeuticsIBA 04/2022
1	Type 2 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 2)IBA 02/2022
1	IntegrinsIBA 01/2022
1	Ferritins (Ferritin)IBA 12/2021
1	L-Lactate Dehydrogenase (Lactate Dehydrogenase)IBA 12/2021
1	Adenosine Triphosphate (ATP)IBA 12/2021
1	palbociclibIBA 07/2021
1	Adiponectin ReceptorsIBA 01/2021
1	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021
1	LeptinIBA 01/2021
1	AdipoRonIBA 01/2021
1	SolutionsIBA 01/2021
1	Anaplastic Lymphoma KinaseIBA 01/2021
1	Tyrosine Kinase InhibitorsIBA 01/2021
1	Trace Elements (Biometals)IBA 01/2021
1	ChemokinesIBA 01/2020
1	Interleukin-33IBA 01/2020
1	Disulfiram (Antabuse)FDA Link 01/2020
1	CytokinesIBA 01/2020
1	Orphan Nuclear ReceptorsIBA 06/2019
1	Member 3 Group A Nuclear Receptor Subfamily 4IBA 06/2019
1	EphA1 Receptor (Eph Receptor)IBA 04/2019

Therapy/Procedure

6	Therapeutics 04/2022 - 12/2009
3	Drug Therapy (Chemotherapy) 07/2021 - 09/2008
1	Fat-Restricted Diet (Diet, Fat Restricted) 01/2021